By Errol C Friedberg
With a Foreword via Sydney Brenner (Nobel laureate in body structure or drugs, 2002)
This biography information the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from delivery, in 1926, to the current, with specific emphasis on his huge, immense medical contributions, together with being the 1st to advance know-how that resulted in gene cloning technology. In 1980, Berg obtained a Nobel Prize in chemistry for this work.
as well as his contributions within the learn laboratory, Berg orchestrated and oversaw a old assembly at Asilomar, California that situated on a threatening controversy surrounding the conception by way of a few of the destructive power of recombinant DNA expertise. This assembly did a lot to stop this controversy and to install position the law of recombinant DNA paintings, hence placing fears to rest.
The recombinant DNA controversy was once a old final result of the invention of gene cloning. particularly, it represented a paramount instance of clinical foresight and due diligence via the medical group, instead of by means of regulatory entities within the usa and plenty of different nations. the last word recognition of gene/DNA cloning ended in a brand new period of recent biology that prospers to the present.
This booklet is aimed essentially at scientists and people in education. The ebook strives to easily offer info for the overall reader, yet isn't particularly adapted for a basic studying audience.
whereas many books hide the recombinant DNA controversy, none have satisfactorily addressed this ancient interval and are usually contradictory concerning the many who is, where's, and why's concerned. also, the good majority of those have been written through non-scientists. This biography of Paul Berg presents entry to varied archived letters and files at Stanford college now not formerly addressed, and to the chronology of occasions as recalled and documented by way of him, in addition to different key personalities, lots of whom have been interviewed.
Readership: Researchers, graduate scholars, undergraduates in existence sciences, drugs and chemistry and lay public.
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Additional info for A Biography of Paul Berg : The Recombinant DNA Controversy Revisited
There he is still frequently sought to lend his vast experience in academic and public policy affairs to the Stanford Department of Biochemistry, the medical school — and sometimes the greater university. Though officially retired from the demanding life of an active scientist directing a busy research laboratory, Berg continues to monitor the progress of contemporary biology by reading the scientific literature and regularly attending seminars at the medical school and elsewhere. Still, he finds time to cultivate both his eclectic taste in nonscientific literature — an appetite too long neglected in his view — and a long-standing and passionate interest in collecting art by contemporary American painters.
Indd xxxi 23-05-2014 12:04:11 b1674 The Recombinant DNA Controversy Revisited xxxii b1674_FM A Biography of Paul Berg Berg posed two fundamental questions. Does the mechanism(s) of gene expression and transcriptional regulation in higher organisms transpire in essentially the same manner as in simple prokaryotes such as the bacterium E. , can bacterial genes be accurately expressed in mammalian cells and retain their functional integrity? And reciprocally, can genes from higher eukaryotes be accurately expressed in bacteria?
Fortunately the tumor does not appear to be life threatening at the time of this writing. But the triumphs have been both bountiful and spectacular: a celebrated career at one of the world’s most prestigious universities during a golden age of science — ultimately acknowledged with a Nobel prize; an opportunity to make a historic contribution to and subsequently formalize one of the most important scientific advances in the history of biology — and in his later years unanticipated personal wealth, affording him and his wife, Millie, the pleasure and fulfillment of modest philanthropy and of making their mutual passion for art a reality.