By George F. Vande Woude, George Klein
Advances in melanoma learn offers necessary details at the intriguing and fast-moving box of melanoma examine. the following once more, amazing and unique studies are provided. Key beneficial properties * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic worth * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability
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Additional info for Advances in Cancer Research, Vol. 77
Mech. Dev. 59, 3–10. , and Bodmer, W. (1997). Proc. Natl. Acad. Sci. A. 94, 10330–10334. , and Hirohashi, S. (1996). Cancer Res. 56, 2213–2217. , and Harowicz, D. (1997). Genes Dev. 11, 3072–3082. , and Berns, A. (1997). EMBO J. 16, 441–450. , and Vogelstein, B. (1996). ) 87, 159–170. , Kinzler, K. , and Clevers, H. (1997). Science 275, 1784–1787. , and Clevers, H. (1998a). Mol. Cell. Biol. 18, 1248–1256. , and Clevers, H. (1998b). Nat. Genet. 19, 279–283. , and Clevers, H. (1993). Nucleic Acids Res.
Stromal cells in the vicinity of propagating tumors serve as the prime source for ErbB-activating ligands, whereas the ex- ErbB/HER Signaling Network of Growth Factor Receptors 43 tracellular matrix surrounding them is a reservoir that can increase local ligand concentrations (see Fig. 2). EGF was the ﬁrst identiﬁed and is the prototype for ligands capable of binding ErbB proteins. These have been shown to harbor the capacity to activate the receptors within a common structural motif of 45–55 amino acids, called the EGF domain.
Hermann, B. , and Kemler, R. (1996). Mech. Dev. 59, 3–10. , and Bodmer, W. (1997). Proc. Natl. Acad. Sci. A. 94, 10330–10334. , and Hirohashi, S. (1996). Cancer Res. 56, 2213–2217. , and Harowicz, D. (1997). Genes Dev. 11, 3072–3082. , and Berns, A. (1997). EMBO J. 16, 441–450. , and Vogelstein, B. (1996). ) 87, 159–170. , Kinzler, K. , and Clevers, H. (1997). Science 275, 1784–1787. , and Clevers, H. (1998a). Mol. Cell. Biol. 18, 1248–1256. , and Clevers, H. (1998b). Nat. Genet. 19, 279–283.