Download Advances in Immunology, Vol. 69 by Frank J. Dixon PDF

By Frank J. Dixon

The Scripps study Institute, los angeles Jolla, CA. newest findings within the box of immunology. changed define structure.

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Nonproductive TCRP rearrangements on both chroniosomes result in programmed death of four of the original nine cells. The frequency of cells with two productive VP -+ (D)Jp rearrangements among the surviving T-cell population is therefore expected to be at most 1/5 (20%). This estimation rests on the following assumptions: (a) absolutely no feedback inhibition of Vp -+ (D)Jb rearrangements by a functional TCRP chain, (b) sufficient time for TCRP rearrangements on the second allele before cells progress to the next developmental stage where the TCRP locus is recombinationally silenced, and (c) no developmental disadvantage of cells with two functional TCRP chains.

Any, even partial, violation of these assumptions would reduce the percentage of double expressing cells. Given the low frequency of cells that express a particular VP element in normal, nontransgenic mice, it was clear that evidence for incomplete allelic exclusion would not be easy to obtain by cell surface staining with antibodies specific for just two different VP elements. 2 elements on one hand and a pool of antibodies recognizing TCRs containing most of the remaining VP elements on the other hand was used.

These chimeric constructs, driven by the proximal lck promotor, were introduced separately into RAG-deficient mice. , 1995). These in vivo cross-linking experiments thus demonstrated that both CD3e- and CD35-derived signals were able to trigger, to an equivalent extent, differentiation of RAG-’- TN thymocytes into DP cells, mimicking pre-TCR function. 5 or CD35 cytoplasmic domains was sufficient to mediate pre-TCR-specific effects further suggested that most of the ITAM motifs in a completely assembled pre-TCR complex might fulfill redundant functions, with the caveat that these experiments could not rigorously exclude the possibility that endogenous CD3 molecules participated in signal transduction.

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