Download Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy PDF

By Karl Maramorosch, Frederick A. Murphy

The first evaluate sequence in virology and released due to the fact 1953, Advances in Virus Research covers a various variety of in-depth experiences, delivering a worthwhile evaluate of the sphere.

  • Contributions from best authorities
  • Comprehensive stories for basic and expert use
  • First and longest-running evaluation sequence in virology

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Additional resources for Advances in Virus Research, Volume 88

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1997). 1 Putative DENV attachment factors and receptors Viral Function in interaction Experimental system (DENV Host factor Cellular function DENV life cycle partner serotype; cell type) References CD14associated proteins Coreceptor for LPS, signaling Attachment E? Internalization? DENV-2; human monocytederived macrophages Chen et al. (1999) CLEC5A Inflammatory response Signaling E DENV-1 to DENV-4; human monocyte-derived and murine bone marrow-derived macrophages Chen et al. (2008) DC-SIGN Cell adhesion; L-SIGN antigen presentation Attachment E DENV-1 to DENV-4; human monocyte-derived DCs Lozach et al.

0) triggers a conformational change in E, resulting in hemifusion between the viral envelope and the endosomal membrane (inset B). Fusion occurs later when virions are transported to Rab7-positive late endosomes (LE) that are rich in anionic lipids, thus releasing viral nucleocapsids/RNA into the cytosol (inset C). The proposed alternative transport of DENV-2 NGC to recycling endosomes (RE) is also represented (dashed line). Revisiting Dengue Virus–Host Cell Interaction 49 membrane during the entry process.

2005). Although the participation of DC-SIGN as an essential host factor for DENV entry during in vivo infection still requires further investigation, these studies clearly support a role for DC-SIGN as a fundamental host determinant of viral pathogenesis. The second C-type lectin identified as a putative DENV receptor/ attachment factor is the mannose receptor (MR). , 2006). In macrophages, the MR was shown to bind to recombinant E glycoprotein produced in mammalian cells as well as virus particles of the four DENV serotypes derived from mosquito cells.

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