By Karl Maramorosch, Frederick A. Murphy
The first evaluate sequence in virology and released due to the fact 1953, Advances in Virus Research covers a various variety of in-depth experiences, delivering a worthwhile evaluate of the sphere.
- Contributions from best authorities
- Comprehensive stories for basic and expert use
- First and longest-running evaluation sequence in virology
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Additional resources for Advances in Virus Research, Volume 88
1997). 1 Putative DENV attachment factors and receptors Viral Function in interaction Experimental system (DENV Host factor Cellular function DENV life cycle partner serotype; cell type) References CD14associated proteins Coreceptor for LPS, signaling Attachment E? Internalization? DENV-2; human monocytederived macrophages Chen et al. (1999) CLEC5A Inflammatory response Signaling E DENV-1 to DENV-4; human monocyte-derived and murine bone marrow-derived macrophages Chen et al. (2008) DC-SIGN Cell adhesion; L-SIGN antigen presentation Attachment E DENV-1 to DENV-4; human monocyte-derived DCs Lozach et al.
0) triggers a conformational change in E, resulting in hemifusion between the viral envelope and the endosomal membrane (inset B). Fusion occurs later when virions are transported to Rab7-positive late endosomes (LE) that are rich in anionic lipids, thus releasing viral nucleocapsids/RNA into the cytosol (inset C). The proposed alternative transport of DENV-2 NGC to recycling endosomes (RE) is also represented (dashed line). Revisiting Dengue Virus–Host Cell Interaction 49 membrane during the entry process.
2005). Although the participation of DC-SIGN as an essential host factor for DENV entry during in vivo infection still requires further investigation, these studies clearly support a role for DC-SIGN as a fundamental host determinant of viral pathogenesis. The second C-type lectin identified as a putative DENV receptor/ attachment factor is the mannose receptor (MR). , 2006). In macrophages, the MR was shown to bind to recombinant E glycoprotein produced in mammalian cells as well as virus particles of the four DENV serotypes derived from mosquito cells.