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By Eric Kvaalen, Philip C. Wankat

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Two cases of men using a paint remover (>80% methylene chloride by weight) in small confined spaces were studied by Snyder et al. (1992a, 1992b) in a hospital emergency room. One reported symptom was severe headache, which disappeared within 24 hours after cessation of exposure. The authors considered this symptom to be associated with methylene chloride neurotoxicity. , recurring severe headaches, numbness/tingling in hands of feet, loss of memory, dizziness) were reported in a group of 150 employees in a fiber plant occupationally exposed to methylene chloride (mean 8-hour TWA=475 ppm) for more than 10 years, when compared to a similar, nonexposed cohort (Soden 1993).

No other transforming genes were found in the nude mouse tumorigenicity assay. The authors were unable to identify any transforming genes other than ras genes in either mouse liver or lung tumors. Based on liver tumor data, they suggested that methylene chloride may affect the liver by promoting cells with spontaneous lesions. Hegi et al. (1994) generated allelotypes of 38 methylene chloride-induced lung carcinomas from female B6C3F1 mice exposed 6 hours/day, 5 days/week for 2 years to 2,000 ppm.

1986). 7). In a logistic regression model, the odds ratio of spontaneous abortion increased with increasing frequency of exposure to methylene chloride, but the sample size was too small for statistical significance. In addition, smoking and alcohol consumption were not considered. The authors mentioned that improved industrial hygiene procedures that eliminated solvent vapors in the workplace may have contributed to an overall decline in rates of spontaneous abortion among pharmaceutical workers during the period in question.

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