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Additional resources for Alcohol and abnormal protein biosynthesis; biochemical and clinical
The patterns that were observed in varying physiologic and pathologic states were highly specific. In several, there was within a single incubate, suppression of synthesis of one or more proteins; no alteration in that of others, and finally, acceleration of others . It appears unlikely that this variation of proteins within a single sample could be the result of variation of amino acid pool or transport. Second, all amino acids were present in the media in a considerable excess over physiologic values, limiting the significance of pool size.
However, several disadvantages are evident. The method depends upon the subjective analysis of density patterns and, depending on the experience of the observer, this may be variable. The technique deals mainly with turnover and does not permit conclusions as to repression of those proteins that do not appear in the (normal) liver incubates. Further, the controls exerted upon the liver in the in vivo situation may be quite different than those in vitro and crucial regulatory factors may be lacking.
Second, uncharged tRNA is known to inhibit initiation nonspecifically. Third, the rate of chain elongation is affected by charging of tRNA. The central position of tRNA charging in the regulation of protein synthesis will emerge again when we consider how this participates in control of bacterial metabolism in response to changes in amino acid availability. V. AMINO ACID SUPPLY AND RNA METABOLISM The adjustment in the protein content of the liver resulting from a change in the amount of protein in the diet is accompanied by parallel alterations in the RNA content of the liver due mainly to variations in the number of ribosomes .