By Sean Murphy (Auth.)
Curiosity within the practical roles of astrocytes within the worried process has grown considerably because it is well-known that those cells not just have their very own pharmacology but in addition unlock neuro- and vaso-active elements. This ebook relates astrocyte pharmacology to telephone functionality for the 1st time, making it an enticing textual content around the neuroscience community.* Discusses the pharmacological law of specific astrocyte services* Covers sensible interactions among those and adjoining CNS telephone varieties* Examines local heterogeneity of astrocytes with admire to receptor expres. Read more...
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Extra info for Astrocytes. Pharmacology and Function
1989b) Glutamate receptor-linked changes in m e m b r a n e potential a n d intracellular C a in primary rat astrocytes. Glia 2 , 2 + 2 + 397-402. , McCarthy, K. , a n d H a r d e n , Τ . K. (1984). Regulation o f cyclic A M P accumulation by peptide h o r m o n e receptors in i m m u n o c y t o c h e m i c a l l y defined astroglial c e l l s . / . Neuro chem. 4 3 , 1 3 1 - 1 3 8 . , a n d Schmidt, M. (1981). Exaggerated cyclic A M P accumulation a n d glial cell reaction in t h e cerebellum d u r i n g Purkinje cell d e g e n e r a t i o n in pcd mutant m i c e .
Focused c o m m u n i c a t i o n over distances large relative to t h e size of a few cells). F o r such c o m m u n i c a tion it w o u l d b e necessary to m o d u l a t e astrocytic g a p j u n c t i o n c o m m u n i c a tion such t h a t a tract of c o n n e c t e d cells within t h e astrocytic p o p u l a t i o n could signal over distances. T h i s idea is n o t u n r e a s o n a b l e given r e c e n t observations t h a t n e u r o l i g a n d s can r e g u l a t e g a p j u n c t i o n c o m m u n i c a t i o n 2.
T h e highly localized calcium r e s p o n s e of p r o c e s s - b e a r i n g type 1-like astroglia resembles t h a t of n e u r o n s a n d f u r t h e r s u p p o r t s t h e c o n c e p t t h a t astrocytes in vivo r e s p o n d to localized n e u r o n a l signals. It is also a p p a r e n t t h a t t h e expression of distinct r e c e p t o r - s i g n a l i n g systems by astroglia does n o t d e p e n d o n contin u e d contact with n e u r o n s . It is w o r t h n o t i n g t h a t pharmacological h e t e r o g e neity s h o u l d n o t b e e q u a t e d with functional h e t e r o g e n e i t y .