By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD
Understand the entire crucial strategies in immunology with Basic Immunology: features and problems of the Immune System! This concise, targeted textual content offers you an up-to-date, available advent to the workings of the human immune procedure.
- Efficiently grasp the immunology info you would like through clinically centred content material, logically prepared via mechanism.
- Apply what you will have realized to real-world events by referencing the appendix of medical situations.
- Enhance your learning with the aid of various full-color illustrations and helpful tables, in addition to precis packing containers, evaluation questions, and a thesaurus of immunology terms.
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- Visualize complicated immunology ideas with a totally up-to-date artwork program.
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Extra resources for Basic Immunology: Functions and Disorders of the Immune System, 4e
B lymphocytes are the only cells that produce antibodies. B lymphocytes express membrane antibodies that recognize antigens, and the progeny of activated B cells, called plasma cells, secrete the antibodies that neutralize and eliminate the antigen. ✹ T lymphocytes recognize peptide fragments of protein antigens displayed on ✹ 22 Chapter 1 – Introduction to the Immune System other cells. Helper T lymphocytes produce cytokines that actiÂ�vate phagocytes to destroy ingested microbes, recruit leukocytes, and activate B lymphocytes to produce antibodies.
Thus, T cells find the antigen they can recognize, and these T cells are activated to proliferate and differentiate. Naive cells that have not encountered specific antigens leave the lymph nodes and reenter the circulation. The effector cells that are generated upon T cell activation preferentially migrate into the tissues infected by microbes, where the T lymphocytes perform their function of eradicating the infection. Specific signals control these precise patterns of migration of naive and activated T cells (see Chapter 6).
We know less about lymphocyte circulation through the spleen or other lymphoid tissues. The spleen does not contain HEVs, but the general pattern of naive lymphocyte migration through this organ probably is similar to migration through lymph nodes. OVERVIEW OF IMMUNE RESPONSES TO MICROBES Now that we have described the major components of the immune system, it is useful to summarize the key features of immune responses to microbes. The focus here is on the physiologic function of the immune system—defense against infections.