Download Bone Marrow-Derived Progenitors (Handbook of Experimental by Katalin Kauser (Editor), Andreas Michael Zeiher (Editor) PDF

By Katalin Kauser (Editor), Andreas Michael Zeiher (Editor)

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Extra info for Bone Marrow-Derived Progenitors (Handbook of Experimental Pharmacology 180)

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2001; Takahashi et al. 1999). Systemic cytokine treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) or granulocyte macrophage-colony stimulating factor (GM-CSF) have been shown to promote cardiac repair and enhance vascularization of severely ischemic tissues (Orlic et al. 2001; Takahashi et al. 1999). -Y. , submitted). There was no difference between CFU-GM and EPC counts between C57Bl/J6 and eNOS-KO mice in response to G-CSF and SCF, suggesting that BMDPC mobilization, irrespective of the progenitor cell type, is independent of eNOS expression and subsequent EDNO availability.

37 38 40 41 41 Abstract Mobilization and recruitment of bone marrow-derived progenitor cells (BMDPCs) play an important role in postischemic tissue repair. Patients with coronary artery disease (CAD) or peripheral vascular disease (PVD) exhibit endothelial dysfunction, and as a result are likely to have a reduced number of progenitor cells mobilized in their peripheral circulation following ischemic injury. Identification of eNOS independent pathways for BMDPC mobilization may have important therapeutic value in this patient population.

1992b), chondrocytes (Johnstone et al. 1998), and adipocytes (Pittenger et al. 1999). These cells are isolated by an initial step of adherence to plastic, followed by a long period of cell culture to eliminate hematopoietic cells that spontaneously adhere to plastic such as granulocytes, monocytes, and macrophages. Due to controversy about whether these cells fulfill the criteria for stem cell activity, they have been variously termed marrow stromal cells (Pochampally et al. 2004; Horwitz et al.

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