Download Breast Cancer: Biological and Clinical Progress: Proceedings by Demetrios A. Spandidos (auth.), L. Dogliotti, A. Sapino, G. PDF

By Demetrios A. Spandidos (auth.), L. Dogliotti, A. Sapino, G. Bussolati (eds.)

The struggle opposed to breast melanoma is predicted to be successfully encouraged through interdisciplinary methods and cross-fertilization among laboratory and medical learn findings. Of significant significance are as a result conferences selling quickly move to scientific purposes of findings through simple scientists. the current quantity, reporting the court cases of the 1991 Biennial convention of the overseas organization for Breast melanoma study, hopes to accomplish this aim by way of featuring the latest observations within the laboratory and their attainable functions for diagnostic reviews and medical remedies. The sections of the booklet concentration first at the oncogenes much more likely excited about mammary tumorigenesis and at the polypeptide elements and steroid hormones affecting proliferation and doubtless inducing carcinogenesis in breast epithelium. a piece is dedicated to the epidemiological reviews and to the id of probability elements, the way to opt for populations at better threat and, in all probability, to assist in fighting the sickness. particular emphasis is given to the institution of diagnostic standards and to the choice of prognostic components, which needs to aid a good healing making plans. it's our wish that this quantity, a well timed replace of the newest advances in particular fields offered by way of easy scientists, pathologists and clinicians will stimulate new insights and progresses major finally to the regulate of breast cancer.

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Additional info for Breast Cancer: Biological and Clinical Progress: Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26–29, 1991

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In breast cancer it's expression is associated with a poor prognosis and 37 thus it is a potential therapeutic target. approaches towards inhibiting c-erbB-2 Various or other tyrosine kinase growth factor receptor function have been discussed. REFERENCES 1. Yarden Y. , Ann. Rev. Biochem. 57:443-478, 1988. 2. , Kapeller R. and Soltoff S. Cell 64:281-302, 1991. 3. Ullrich A. and Schlessinger J. Cell 61:203-212, 1990. 4. W-H. W. Proc. Natl. Acad. Sci. USA 87:7270-7274, 1991. 5. , Ullrich A. and Schlessinger J.

H. and Schubert D. Nature 348:257-260, 1990. 16. , Slamon D. E. Science 249:1552-1555, 1990. 17. Yarden Y. and Peles E. Biochemistry 30: 35433550, 1991. 18. V. I. Nature 339:230-231, 1989. 19. Yarden Y. Proc. Natl. Acad. Sci. USA 87:25692573, 1990. 20. , Hung M-C. A. Cell 45:649-657, 1986. 38 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. l. A. EMBO J. 7:20432052, 1988. E. J. Nature 339:587, 1989. E. J. Protein Engineering 3:245-248, 1990. l. A. Proc. Nat!. Acad.

Even more remarkable was the similarity between these mammary hyperplasias and the pregnancy-dependent tumors or plaques of the GR/A mouse. The GR plaque differs from the int-2 transgenic hyperplasia only in the focal nature of the lesion in the GR as opposed to the diffuse involvement of the transgenic mammary gland. However, the severity of the hyperplasia in the transgenic mammary gland is variable, leading to background. focal lesions that stand out from the These persistent foci may represent local transformation and warrant further study.

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