By E. Blind, D. Flentje, S. Fischer (auth.), Professor Dr. med. Heinrich Schmidt-Gayk, Franz Paul Armbruster Dipl.Ing. (chem.), Professor Dr. Roger Bouillon (eds.)
Calcium metabolism is regulated through 3 particular hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP additionally performs a tremendous half in calcium rules, and its focus in urine could be taken as a degree of parathyroid functionality. tools for quantitative size of, e.g. calcium-regulating hormones and nutrition D metabolites in addition to of cAMP are totally invaluable for secure differential prognosis of illnesses of the parathyroid like hypo- and hyperparathyroidism. during this monograph all almost immediately to be had tools are summarized to whether they could already be acquired as try out kits or are nonetheless being verified. Radioimmunoassays for a number of the peptide fragments reminiscent of 53-84, 44-68, 28-48, and 1-34 are defined, as are immunochemiluminescence equipment and adenylate cyclase bioassays. an analogous is correct for the nutrition D metabolites, the place some of the assays for calcidiol and calcitriol reminiscent of HPLC, protein-binding assay with moment antibody separation, and double antibody RIA are de§ scribed. ultimately, decision of calcitonin and cAMP is mentioned intimately. it is a essentially and clinically orientated monograph for operating within the fields of inner drugs, endocrinology, and laboratory medication.
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Extra resources for Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application
This hypothesis, like that of other free steroid and thyroid hormones, is based on both clinical and experimental observations [8, 10,46]. Abnormal concentrations of serum 1,25-(OHhD have been documented in many circumstances and diseases and interpretation of serum measurements therefore requires other clinical and biochemical data. Low levels of 1,25(OHhD can be due to deficient substrate concentrations, organic or functional enzyme deficiency, low circulating DBP levels, or other less well defined reasons (Table 4).
The same rule applies for the global estimation of the vitamin D status. Measurements of vitamin D, of course, do find an application in evaluating the vitamin content of natural or vitamin D-enriched food or pharmaceutical products. Clinical Applications for the Measurements of 25-Hydroxyvitamin D2 and D3 Vitamin D is rapidly converted into 25-hydroxyvitamin D in the liver hepatocytes by a microsomal and/or a mitochondrial vitamin D-25-hydroxylase system both using a P-450 cytochrome. , it also 25-hydroxylates cholesterol).
Since skin pigmentation decreases in populations living in more northern climates, some authors believe that the white human race originates from a progressive mutational adaptation to decreased sun exposure to avoid endemic vitamin D deficiency . Indeed, populations with increased skin pigmentation (blacks in North America and many immigrants from Mediterranean or Indian origin in western Europe) nearly always have lower 25-0HD levels than the "original" white population living in the same area.