Download Chemoprevention of Cancer: A Clinical Update by C. I. Amos, W. Xu, M. R. Spitz (auth.), Prof. Dr. med. PDF

By C. I. Amos, W. Xu, M. R. Spitz (auth.), Prof. Dr. med. Hans-Jörg Senn, Dr. Alberto Costa M.D., Prof. M.D., Ph.D. V. Craig Jordan (eds.)

This quantity comprises a part of the papers given on the moment annual convention of the newly based overseas Society of melanoma Chemoprevention held in August 1997 in St. Gallen, Switzerland. Pharmacologic intervention in human carcinogenes is in its very infancy, and across the world coordinated efforts to struggle the evolution of human cancers are just now taking form. this is often one of many first efforts to unite specialists of all significant teams and facilities all over the world within the hugely attention-grabbing and thought-provoking box of chemoprevention of melanoma, specially of the breast, colon and prostate.

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Together with rehabilitation, this kind of intervention falls within the scope of patient management, and it is particularly relevant in the case of chronic degenerative diseases such as cancer, which often pose the problem of incomplete recovery and a trend to recurrences and complications. Approaches to Cancer Prevention Figure 1 shows the time-course of possible intervention strategies against cancer, as related to the different steps of the carcinogenesis process and to the growth patterns of the neoplastic mass.

Grune and Stratton, New York, pp 517-540 Wattenberg LW, Bueding E (1986) Inhibitory effects of 5-(2-pyranizyl)-4-methyl-l,2-dithiol3-thione (oltipraz) on carcinogenesis induced by benzo[a ]pyrene, diethylnitrosamine and uracil mustard. Carcinogenesis 7:1379-1381 Weinstein IB (1988) Strategies for inhibiting multistage carcinogenesis based on signal transduction pathways. Mutat Res 202:413-420 Yu R, Jiao J-J, Duh J-L, Tan T-H, Tony Kong A-N (1996) Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N -terminal kinase 1.

Some mechanisms, such as "antioxidant activity and scavening of reactive oxygen species", are rather generic, and can be further subdivided according to the particular mode of action of each agent. Multiple Mechanisms of Chemopreventive Agents Table 1 shows a schema of individual mechanisms by which inhibitors can exert their protective effects. Actually, it is rather uncommon for a given agent to be so specialized as to intervene at one level only. Most chemopreventive agents are known or thought to work through multiple mechanisms becal,lse of the involvement of pleiotropic properties.

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