Download Clinical Nephrotoxins by M. deBroe, et al. PDF

By M. deBroe, et al.

Show description

Read Online or Download Clinical Nephrotoxins PDF

Similar clinical books

Quality: Its Definition and Measurement As Applied to the Medically Ill

Caliber, as exemplified by means of Quality-of-life (QoL) review, is often mentioned between overall healthiness care execs and infrequently invoked as a objective for development, yet someway not often outlined, while it truly is on a regular basis assessed. it truly is understood that a few scientific sufferers have a greater QoL than others, yet may still the QoL completed be in comparison to an incredible kingdom, or is it too own and subjective to gauge?

Steroid Hormone Receptors: Basic and Clinical Aspects

The previous few years have witnessed the emergence of steroid hormones because the ask yourself molecules which generate as a lot dialogue within the medical literature as they do in a customary front room. This transition has been due to the the super public and clinical curiosity within the general functioning of the hor­ mones to boot their instructed involvement in different scientific stipulations.

Netter's Infectious Disease, 1e

Netter’s Infectious ailments offers a entire but concise evaluate of present worldwide infectious disorder matters. Elaine Jong and Dennis Stevens, and panel of specialist participants hide the fundamentals of the sector utilizing appealing Netter illustrations and obtainable "need to grasp" details on significant stipulations and problems—including vaccine-preventable illnesses, drug-resistant Staph and TB infections, pandemic flu, echinococcosis, and Chagas illness.

Additional resources for Clinical Nephrotoxins

Example text

Intensive Care Med 2000; 26: 915-921. De long PE, Statius van Eps LW. Sickle cell nephropathy: new insights into its pathophysiology. Kidney Int 1985; 27: 711-719. Allen M, Lawson L, Eckman lR, Delaney V, Bourke E. Effects of nonsteroidal anti-inflammatory drugs on renal function in sickle cell anemia. Kidney Int 1988; 34: 500-506. Porter GA. Contrast associated nephropathy. Am J Cardiol 1989; 64: 22E-26E. Rihal CS, Textor SC, Grill DE, Berger PB, Ting HH, Best PJ, Singh M, Bell MR, Barsness GW, Mathew V, Garratt KN, Holmes DR Jr.

E. hydrophobicity and acidity, and lack of molecular structure requirement [68, 69]. The molecular biology of the OAT transporter family Several isoforms of OAT1 (rat, human, mice OAT1) have been cloned and their functional properties examined in different cultured cell systems and Xenopus oocytes. Detailed molecular structures and functional characteristics have been recently reviewed [29, 38, 39] (Figure 5). OAT1 belongs to a subgroup of a newly identified transporter family, the organic ion transporter family, which comprises other OAT isoforms, OAT2, and OAT3.

Because probenecid, PGE2 and methotrexate are secreted in human and rat, this lack of transport suggests that other OAT isoforms or transport proteins are involved in their secretion. Recently, OAT2 and OAT3, two OAT1 isoforms, have been identified. OAT2 mRNA is predominantly expressed in the liver, and weakly in the kidney. In contrast OAT3 mRNA is expressed in the kidney, as well as in the liver and the brain [80a]. The substrate spectrum of OAT2 and OAT3 is diverse like that of OAT1 [81], but in contrast to OAT1, transport is not dependent on α-ketoglutarate, and a concentration gradient is sufficient to allow transport.

Download PDF sample

Rated 4.53 of 5 – based on 13 votes