Download Clinical Neuroimmunology: Multiple Sclerosis and Related by Patricia K. Coyle MD (auth.), Syed A. Rizvi, Patricia K. PDF

By Patricia K. Coyle MD (auth.), Syed A. Rizvi, Patricia K. Coyle (eds.)

Clinical Neuroimmunology: a number of Sclerosis and similar problems serves as an quintessential source for physicians drawn to, and working with, this very complicated and evolving department of neurology. This entire titleprovides an creation to easy neuroimmunology and ideas of immunotherapy and in addition serves as a radical consultant to immune-mediated problems of the primary and peripheral apprehensive process, in addition to different systemic issues with an important neuroimmunologic part. The chapters are written through specialists of their fields and contain the hottest medical info. This quantity is made to simplify advanced immunological mechanisms and to target useful patient-related matters. Clinical Neuroimmunology: a number of Sclerosis and similar issues is a useful addition to the literature and should be of vital curiosity toneurologists, citizens and fellows, internists, and basic practitioners who deal with sufferers with neurologic issues and different systemic autoimmune diseases.

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Additional info for Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders

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MMP-2 to TIMP-2 ratio is increased in the CSF and serum of relapsing MS, with evidence of intrathecal MMP-2 production [108]. Serum MMP-2 and MMP-2/TIMP-1 ratio is said to be elevated in progressive MS [109]. CNS Cells and Components Microglia Microglia are the resident CNS macrophages as well as immune cells. They act as APCs, produce cytokines, and are involved in phagocytosis. Activated microglia are noted in all MS patients, but are especially associated with the progressive subtypes. Activated microglia and macrophages produce cytotoxic molecules including proinflammatory and cytotoxic cytokines, reactive oxygen and nitrogen intermediates, and proteolytic and lipolytic enzymes [80].

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136. Pomicter AD, Shroff SM, Fuss B, et al. Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis. Brain. 2010;133:389–405. 137. Colucci M, Roccatagliata L, Capello E, et al. The 14-3-3 protein in multiple sclerosis: a marker of disease severity. Mult Scler. 2004;10:477–81. 138. Alvarez JI, Cayrol R, Prat A. Disruption of central nervous system barriers in multiple sclerosis. Biochim Biophys Acta. 2010. 1016. 139. Bennett J, Basivireddy J, Kollar A, et al.

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