Download Clinical Research Methods for Surgeons by Eugene H. Blackstone MD (auth.), David F. Penson MD, MPH, PDF

By Eugene H. Blackstone MD (auth.), David F. Penson MD, MPH, John T. Wei MD, MS (eds.)

Clinical study tools for Surgeons is a finished consultant for the surgical scientist, and serves as either a severe evaluate of latest literature and a reference consultant for medical learn methodologies as they practice to surgical procedure. The textual content addresses the medical study questions dealing with twenty first century surgeons, and gives transparent course on easy methods to comprise subtle study options into perform. as well as the surgical generalist, this functional quantity is in particular orientated to surgeons who deal with particular ailments, but haven't any unmarried source to facilitate medical examine in those particular areas.
This entire and easy-to-use advisor encompasses the whole means of medical research layout, software, and review. half One is geared toward the younger healthcare professional approximately to have interaction in new stories, and provides a basic assessment of the infrastructure of scientific study. elements and 3 are geared in the direction of skilled investigators drawn to pursuing scientific learn and surgeons reviewing the literature for functional program. half specializes in examine layout and similar statistical concerns, whereas half 3 is worried with measuring and assessing the end result of scientific reviews. half 4 provides issues of curiosity to the lively investigator, reminiscent of caliber of care and cost-effectiveness analyses. medical learn tools for Surgeons is proper to either starting investigators and confirmed researchers, and addresses the original issues of surgical ailments and recognizes that they require certain ways to accommodate scientific questions.

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32. Bertranou EG, Blackstone EH, Hazelrig JB, Turner ME, Kirklin JW. Life expectancy without surgery in tetralogy of Fallot. Am J Cardiol 1978;42:458–466. 33. Kirklin JW, Blackstone EH, Pacifico AD, Brown RN, Bargeron LM, Jr. Routine primary repair vs twostage repair of tetralogy of Fallot. Circulation 1979;60:373–386. 34. Blackstone EH, Kirklin JW, Bertranou EG, et al. Preoperative prediction from cineangiograms of postrepair right ventricular pressure in tetralogy of Fallot. J Thorac Cardiovasc Surg 1979;78:542–552.

This motivated the inclusion of what has come to be known as the “Nuremberg Code” in the final trial judgment (3). The full text of the code is available elsewhere (4), but, in summary it states that: Chapter 2 / Ethical Issues in Clinical Research 33 • Subjects participating in research should give informed consent without coercion. • The anticipated benefits of the study should justify the research and the risks associated with it. • Human studies should be based on prior animal studies and knowledge of the natural history of the condition under study.

Rubin DB. Bias reduction using Mahalanobis’ metric matching. Biometrics 1980;36:295–298. 52. Rosenbaum PR, Rubin DB. The bias due to incomplete matching. Biometrics 1985;41:103–116. 53. Kirklin JW, Vicinanza SS. Metadata and computer-based patient records. Ann Thorac Surg 1999;68:S23–S24. 54. Williams WG, McCrindle BW. Practical experience with databases for congenital heart disease: A registry versus an academic database. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2002;5:132–142. 55. Lauer MS, Blackstone EH.

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