Download COX-2 Inhibitor Research by Maynard J. Howardell PDF

By Maynard J. Howardell

COX-2 Inhibitors are newly constructed medicinal drugs for irritation that selectively block the COX-2 enzyme. blocking off this enzyme impedes the creation of the chemical messengers (prostaglandins) that reason the soreness and swelling of arthritis irritation. Cox-2 inhibitors are a brand new type of nonsteroidal anti inflammatory medicinal drugs (NSAIDS). simply because they selectively block the Cox-2 enzyme and never the Cox-1 enzyme, those medications are uniquely various from conventional NSAIDS. This e-book explores new examine during this box.

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Extra resources for COX-2 Inhibitor Research

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A number of assay systems have developed to evaluate the ability of NSAIDs to inhibit COX. These include purified enzyme assays, microsomal membrane preparations from cells expressing COXs, disrupted cells, whole cells, and whole blood, to name a few. The selectivity for each isoform can be expressed as the COX-2/COX-1 IC50 ratio. Inasmuch as the absolute IC50's and selectivity ratios will vary from assay to assay, it is impossible to directly compare IC50's. , 1999). nonselective COX inhibitor, such as Indomethacin, Sulindac, Ketoprofen; 2).

These drugs act primarily by inhibiting cyclooxygenase enzyme, which has two isoforms, COX-1 and COX2. NSAIDs are sometimes stated that all “traditional” NSAIDs inhibit both COX-1 and COX2. It is therefore imperative to divide them. When evaluating the cellular mechanisms mediating the anti-neoplastic of NSAIDs (Raz, 2002). NSAIDs have been postulated to inhibit carcinogeneisi by both COX-2 dependent and COX2-independent mechanism (Gupta and DuBois, 2000; DuBois, 2000). It is more important that specific COX-2 inhibitors have been tried experimentally and clinically and found effective.

It is indicated that eview of available literature shows 1). Sulindac and COX-2 inhibitors are effective in preventing as well as regressing familial adenomatous polyposis. Whereas, they have not been demonstrated to prevent cancer in these patients. 2). 3). COX-2 inhibitors may be of value in the treatment of reflux oesophagitis, pancreatitis and hepatitis, although carefully planned randomized controlled clinical trials demonstrating their efficacy need to be conducted. 6). , 2003). Importantly, selective COX-2 inhibitors do not inhibit platelet function and cause fewer gastrointestinal side effects (peptic ulcer disease) than traditional nonsteroidal antiinflammatory drugs.

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